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  • The clinically efficacious properties and mechanisms of collagen peptide

    Date of posted:2015-11-03

    Click blow count:5565

    Science and Research

     In the past years, research has begun to shed light on some of the clinically efficacious properties and mechanisms of collagen peptide on biological regulation, providing evidence of its additional advantages as a nutritional bioactive. The benefits of TruMarine™ Collagen have been demonstrated through clinical studies. TruMarine™ Collagen achieves optimal results to ensure the cohesion, elasticity and regeneration of skin, hair, bone and joint.

    SKIN

    Collagen is a major constituent of the connective tissues of human. TruMarine™ Collagen improves skin properties to obtain an optimal skin condition and to promote beauty from within.

    Collagen dermatologist studyStudy 1: Clinical test of the effects on human skin

    Methodology: Placebo-controlled, double blind study on healthy women aged 40-54 years ingesting either a placebo drink (50ml) or a drink containing 5g or 10g of collagen peptide, daily after dinner for 7 weeks.

    Observations: After 3 weeks and 7 weeks, a dermatologist asked the volunteers about their subjective impressions of facial skin condition (whether it was worse, normal or better as compared to before the test).

    At 3 weeks, only 10% of the placebo group answered “better”, while this value was 41% in the 5g per day group and 62% in the 10g per day group.
     
    After 7 weeks, the value was 20% in the placebo group, but 81% in the 5g per day group and 74% in the 10g per day group. These results confirm that 70~80% of woman are able to observe the effects of collagen peptide ingestion on the skin.
     
    Study 2: Effects on skin – Increase of moisture content in the stratum corneum

    Methodology: Double blind test carried out on young healthy female volunteers who drink a beverage containing 10 g of marine collagen or placebo every day for 2 months.

    Observations: The study reported an increase in the water absorbing capacity of the stratum corneum of the skin during the test period. The increase in water absorbing capacity of the collagen-ingesting group was higher than that of the placebo group at 1 month and the difference became larger when the test period was extended to 2 months.

    Study 3: Effects on dermis – Microscopic observation of the skin

    Methodology: Marine collagen peptide was added to the diet of pigs such that they were ingesting a dose of 0.2 g/kg BW/day for 62 days.

    Observations: The skin was subjected to microscopic observation of collagen fibrils. The diameter and density of collagen fibrils increased significantly when collagen peptide was administered, and this was associated with an increase of the density of fibroblasts.

    Study 4: Prevention of UVB induced skin damage

    Methodology: Marine collagen peptide was administered to hairless mice at a dose of 0.2 g/kg body weight/day, and UVB irradiation was repeatedly performed at 0.3 mW/cm2 for 6 weeks.

    Observations: Repeated UVB irradiation induced the formation of wrinkles, a decrease in the water content of the stratum corneum, hyperplasia with a thick epidermis, and a decrease in the amount of type I collagen in the blood. The study showed that in mice that ingested collagen peptides, the water content of the stratum corneum was significantly higher and UVB induced skin damages were reduced. Moreover, when marine collagen peptides were administrated, no significant hyperplasia was observed and the amount of type I collagen did not decrease.

    These results suggest that the daily ingestion of marine collagen peptide suppresses the skin damage induced by repeated UVB irradiation. The ingested collagen peptides suppress UVB damage or promote recovery after it. They are partly digested into small oligopeptides and absorbed into the blood

    JOINT

    As we age, our body loses its ability to make collagen and joints become stiff and less flexible. Athletes are also effected by joint pain due to their intensive activity. Clinical trials have shown that TruMarine™ Collagen significantly reduces joint pain and discomfort for an improved mobility by repairing joint matrix degeneration.

    Study 4: Effects on Joint pain

    Methodology: 24-Week prospective, randomized, placebo-controlled double-blind test study on the use of marine collagen hydrolysate as a dietary supplement. Athletes with activity-related joint pain were administrated collagen peptide (10g/day) or placebo.

    Observations: Joint pain at rest and for walking was considerably improved. Ingestion of collagen peptides directly improves joint mobility and comfort.

    BONE

    If the amount of daily intake of protein is low, bone mineral density decreases. In addition, low protein conditions may be a cause of lower bone mineral density in the elderly. In vivo experimentation showed that TruMarine™ Collagen helps to maintain bone health and restore bone mineral density.

    Study 5: Effects on Bone density in low protein condition

    Methodology: Animal experiment to investigate the effects of collagen ingestion under low protein conditions. Mice were administrated collagen or casein.

    Observations: The Bone mineral density was significantly higher for mice that were given food containing 6% casein + 4% collagen compared to mice given only 10% casein. These results suggest that collagen is superior to casein in its potential to enhance bone matrix and density.

     

    prve:Collagen enhances skin beauty

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